In recent decade, peptides have become a coveted active ingredient in men's  skincare products. These tiny proteins have clinically proven efficacy in keeping our skin firm, smooth, and youthful. It has become a gold standard in anti-aging men's skincare products because of its efficacy and how easy it is to formulate into products.  Peptides have few ingredient contradictions and works better when included with other active ingredients to amplify and deliver better results. 

What Are Peptides?

Peptides are essentially small but mighty compounds found in our skin. Think of them as the architects behind the scenes, composed of short chains of amino acids. Their role is pivotal in maintaining the structure of our skin by facilitating the creation of crucial proteins like collagen and elastin. 

Matrixyl serum, urth

These tiny proteins are key in keeping our skin firm and youthful.

However, as we grow and age, our body’s ability to produce these proteins diminishes, leading to wrinkles, skin sagging, and a loss of elasticity. Peptides come to the rescue by sending signals to our skin cells, encouraging them to step up their production of collagen and elastin. This ignites a revitalization process, aiding in the fight against visible signs of aging. In essence, peptides serve as the invisible men's skincare heroes, ensuring our skin remains firm, healthy, resilient and youthful.

Peptides in Skincare


Commercial Name


Matrixyl (Palmitoyl Pentapeptide-4)

Matrixyl 3000

Stimulates collagen production, improving skin firmness and elasticity.

Palmitoyl Tripeptide-1 (formerly known as Palmitoyl Oligopeptide)


Boosts collagen and glycosaminoglycan synthesis, enhancing skin repair and thickness.

Palmitoyl Tripeptide-38

Matrixyl Synthe'6

Stimulates the synthesis of six major components of the skin matrix, including collagen and hyaluronic acid, to smooth wrinkles and improve skin texture.

Argireline (Acetyl Hexapeptide-8)


Reduces the appearance of wrinkles by inhibiting muscle contractions.

Copper Peptide (Copper Tripeptide-1)

ProCyte Copper Peptide

Promotes wound healing, collagen production, and has antioxidant properties.

Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate)


Mimics snake venom to reduce muscle contractions and smooth wrinkles.

Palmitoyl Tetrapeptide-7


Reduces inflammation and the damage caused by exposure to UV radiation.

Acetyl Tetrapeptide-5


Reduces eye puffiness and dark circles by inhibiting fluid buildup and improving skin elasticity.



Promotes skin healing, increases collagen synthesis, and improves skin firmness.



Reduces the depth of wrinkles, particularly around the eyes and forehead.


Peptides in skincare can be broken down into a few categories.  Each peptide category has different value added benefits to the skin.  


peptides in skincare, urth
Peptide Category Peptides Benefits
Signal Peptides - Palmitoyl Pentapeptide-4 (Matrixyl) - Stimulates collagen production, reducing wrinkles and fine lines
- Palmitoyl Tripeptide-1 - Enhances skin repair and elasticity
- Palmitoyl Tripeptide-38 (Matrixyl synthe'6) - Boosts collagen synthesis, improves skin texture and firmness
Carrier Peptides - Copper Tripeptide-1 (Copper Peptide) - Delivers copper to skin cells, promoting wound healing, collagen production, and has antioxidant properties
- Manganese Peptide - Facilitates enzyme activation, aids in antioxidant defense and skin repair
Neurotransmitter-Inhibiting Peptides - Acetyl Hexapeptide-8 (Argireline) - Reduces muscle contractions, diminishing the depth of wrinkles, particularly on the forehead and around the eyes
- Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake) - Mimics the effect of snake venom to relax facial muscles and smooth wrinkles
- Pentapeptide-18 - Reduces expression lines by modulating muscle contraction
Enzyme-Inhibiting Peptides - Soy Peptides - Inhibit enzymes that break down collagen, protecting the skin’s structural integrity
- Rice Peptides - Reduces the activity of proteases, enzymes that can degrade the skin matrix, promoting skin firmness and elasticity
Structural Peptides - Palmitoyl Tetrapeptide-7 - Reduces inflammation and glycation damage, promoting smoother and more even-toned skin
- Palmitoyl Tripeptide-38 (Matrixyl synthe'6) - Supports skin’s structure, enhances skin repair, and boosts collagen production


How to Use Peptides in Your Men's Skincare Routine

Adding peptides to your men's skincare routine is straightforward. Look for men's skincare products like serums, moisturizers, and eye creams that have peptides infused as a key active in the formulation and an effective percentage.  Look for peptides formulated with other key skincare actives like niacinamide, squalene, tranexamic acid, vitamin C, Vitamin E, Hyaluronic Acid to amplify and boost the desired results. Always apply peptide-rich products after washing your face and toning but before heavier creams or oils. This allows the peptides to penetrate deeply and work effectively. 

man using peptide eye cream, urth

Look for peptides in the best men's face care products; day creams, night creams, serums, eye creams, hair treatment products, lip balms and more.  Peptides are effective ingredients, backed by clinical studies, when used at manufacturer’s recommended usage percentages.  Peptides in skincare are expensive so expect to pay a premium for the peptide infused products.  

Peptides and Compatibility with Other Skincare Actives

Peptides are versatile and can be effectively combined with other active skincare ingredients to enhance the overall benefits of the formulation. Here’s a look at some of the top skincare actives that pair well with peptides.  Look for one or more of the following ingredients. 



Hyaluronic Acid

- Deep hydration


- Improved skin elasticity

Vitamin C

- Brightens skin


- Boosts collagen production


- Provides antioxidant protection


- Improves skin elasticity


- Enhances barrier function


- Evens skin tone


- Promotes cell turnover


- Reduces wrinkles


- Improves skin texture

Antioxidants (e.g., Vitamin E, Green Tea)

- Protects against environmental damage


- Reduces inflammation


- Strengthens the skin barrier


- Retains moisture

Alpha Hydroxy Acids (AHAs)

- Exfoliates the skin


- Promotes smoother texture


- Brightens complexion


- Provides lightweight hydration


- Locks in moisture


- Reduces puffiness


- Improves circulation

Panthenol (Vitamin B5)

- Soothes and repairs the skin


- Enhances moisture retention


Peptides are a powerful ingredient in the fight against aging, offering numerous benefits from boosting collagen production to reducing wrinkles. urth’s Hydrating Mask Complex is an anti aging mask infused with a trio of neuro peptides; Argireline acetyl hexapeptide 8, palmitoyl tetrapeptide 7, and rice protein peptide along with vitamin C, DMAE, and hyaluronic acid. Incorporating peptide-rich products into your skincare routine can help maintain a youthful, radiant complexion. Whether you’re dealing with fine lines, sagging skin, or just want to enhance your skin’s overall health, peptides are a valuable addition to any men’s skincare regimen.


A men's skincare routine with the best men's face care products can help maintain a healthy clear complexion, minimizing redness and appearance of large pores on the face. Urth has curated skincare kits for men to simplify men's skincare routine. We’ve taken out all the guesswork and created skincare kits for men to elevate your skincare ritual. These natural, clean and botanical-powered products are formulated with chamomile, green tea, ginseng, and pure essential oils to nourish, soothe, and calm facial redness. Perfect for all skin types—including sensitive, dry, combination, and oily skin—Urth's Skin Solutions provides an easy, effective way to achieve healthier, clearer complexion.